The mitonuclear compatibility species concept

The mitonuclear compatibility hypothesis of sexual selection.

Why females assess ornaments when choosing mates remains a central question in evolutionary biology. We hypothesize that the imperative for a choosing female to find a mate with nuclear oxidative phosphorylation (OXPHOS) genes that are compatible with her mitochondrial OXPHOS genes drives the evolution of ornaments. Indicator traits are proposed to signal the efficiency of OXPHOS function thus ...

Aging: Seeking Mitonuclear Balance

Metabolic imbalances accompany the aging process in many organisms, and signaling mechanisms that allay or prevent these imbalances can extend lifespan. Two recent studies by Auwerx and colleagues, including one in this issue, identify a conserved signaling network centered on mitochondrial stress responses that promotes longevity in response to changes in mitochondrial translation and NAD(+) m...

The Relational Species Concept

Tisssue factor and factor viia cross-species compatibility Tisssue factor and factor viia cross-species compatibility

1. Astract 2. Introduction 3. TF and FVIIa 3.1. Purification, cloning and expression of TF 3.2. TF structure and function 3.3. Purification, cloning and expression of FVII 3.4. FVIIa structure and function 3.5. Interaction of FVIIa with TF 3.6. Binding of human FVIIa to sTF, lipidated TF and cell surface TF 3.6.1. FVIIa binding to sTF 3.6.2. FVIIa binding to lipidated TF and to cell surface TF ...

The Concept of Compatibility: Towards a Functional Understanding of Immunohematology

A variety of strategies has been developed to assure safety of hemotherapy. Such strategies aim in particular at avoiding transfusion-transmitted infections. Safety of hemotherapy requires – in addition to safety of transfusion from infections – tolerance of the recipient towards the blood component to be transfused and tolerance of the blood component to be transfused towards the recipient, i....